Ellagic acid metabolism as a source of dietary MR1 ligands
David O’Sullivan *, Carl J H Wang *, Jeffry S Tang, Ruth Stephens, Sophie Faulkner, Katie Gell, Yanyan Li, Alissa Cait, Mitchell McInerney, Anthony W Purcell, Jamie Rossjohn, Jerome Le Nours *, Olivier Gasser *
DOI: 10.1093/jimmun/vkaf346
2026
Impact of non-digestible carbohydrates and prebiotics on immunity, infections, inflammation and vaccine responses: a systematic review of evidence in healthy humans and a discussion of mechanistic proposals
Hediye Arioz Tunc *, Philip C Calder *, Alissa Cait, Georgina F Dodd, Naschla Y I Gasaly Retamal, Damien Guillemet, Daniel James, Konrad J Korzeniowski, Anna Lubkowska, Alexandra Meynier, Weronika Ratajczak, Frédérique Respondek, Clémentine Thabuis, Elaine E Vaughan, Naomi Venlet, Gemma Walton, Olivier Gasser *, Paul de Vos *
DOI: 10.1080/10408398.2025.2514700
2025
Potential Detrimental Interactions Between Metformin and Supplemental Dietary Fiber in Type 2 Diabetes
Rosemary M Hall, Amber Parry-Strong, David O’Sullivan, Jeremy D Krebs, Olivier Gasser
DOI: 10.1111/1753-0407.70101
2025
Disrupting and restoring protection: maternal antibiotic exposure and neonatal IgA transfer via breastfeeding
Olivier Gasser, Gergely Toldi
DOI: 10.1038/s41390-025-03992-4
2025
Pharmacokinetics of major indigo naturalis indole alkaloids in humans and their association with systemic aryl hydrocarbon receptor activity
Jeffry S Tang, Alissa Cait, David O’Sullivan, Craig Waugh, Roel van Ginkel, Emillie Passfield, Katie Gell, Yanyan Li, Sophie Faulkner, Patries M Herst, Olivier Gasser
DOI: 10.1016/j.bcp.2025.116805
2025
Controlled infection with cryopreserved human hookworm induces CTLA-4 expression on Tregs and upregulates tryptophan metabolism
Francesco Vacca, Thomas C Mules, Mali Camberis, Brittany Lavender, Sophia-Louise Noble, Alissa Cait, Kate Maclean, John Mamum, Bibek Yumnam, Tama Te Kawa, Laura Ferrer-Font, Jeffry S Tang, Olivier Gasser, Graham Le Gros, Stephen Inns
DOI: 10.1080/19490976.2024.2416517
2025
Tissue-specific contribution of mucosal-associated invariant T cells to allergic airway inflammation
Alissa Cait, Katherine Woods, Karmella Naidoo, Katie Gell, Alfonso Schmidt, Rosemary Jackson, Alix Grooby, David O’Sullivan, Olivier Gasser
DOI: 10.1111/all.16038
2024
Polyphenol and glucosinolate-derived AhR modulators regulate GPR15 expression on human CD4+ T cells
Jeffry S Tang, Ruth Stephens, Yanyan Li, Alissa Cait, Katie Gell, Sophie Faulkner, Alix Grooby, Patries M Herst, David O’Sullivan, Olivier Gasser
DOI: 10.1016/j.jnutbio.2023.109456
2024
Controlled Hookworm Infection for Medication-free Maintenance in Patients with Ulcerative Colitis: A Pilot, Double-blind, Randomized Control Trial
Thomas C Mules, Brittany Lavender, Kate Maclean, Francesco Vacca, Sophia-Louise Noble, Bibek Yumnam, Tama Te Kawa, Alissa Cait, Jeffry Tang, David O’Sullivan, Olivier Gasser, James Stanley, Graham Le Gros, Mali Camberis, Stephen Inns
DOI: 10.1093/ibd/izad110
2024
A randomised controlled trial of long NY-ESO-1 peptide-pulsed autologous dendritic cells with or without alpha-galactosylceramide in high-risk melanoma
Nathaniel Dasyam #, Katrina J Sharples #, Catherine Barrow #, Ying Huang, Evelyn Bauer, Brigitta Mester, Catherine E Wood, Astrid Authier-Hall, Marina Dzhelali, Tess Ostapowicz, Rajiv Kumar, Jessica Lowe, Alice Maxwell, Olivia K Burn, Geoffrey M Williams, Sarah E Carley, Graham Caygill, Jeremy Jones, Susanna T S Chan, Victoria A Hinder, Jerome Macapagal, Monica McCusker, Robert Weinkove, Margaret A Brimble, Gavin F Painter, Michael P Findlay, P Rod Dunbar, Olivier Gasser, Ian F Hermans
DOI: 10.1007/s00262-023-03400-y
2023
Importance of the endometrial immune environment in endometrial cancer and associated therapies
Hannah van der Woude, Kathryn Elizabeth Hally, Margaret Jane Currie, Olivier Gasser, Claire Elizabeth Henry
DOI: 10.3389/fonc.2022.975201
2022
MR1-dependence of unmetabolized folic acid side-effects
Jeffry S Tang, Alissa Cait, Reuben M White, Homayon J Arabshahi, David O’Sullivan, Olivier Gasser
DOI: 10.3389/fimmu.2022.946713
2022
Goat Milk-Derived Lipids Restrain NK T Cell-Dependent Eosinophilic Inflammation in a Murine Model of Atopic Dermatitis
Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine
Alissa Cait, Anna Mooney, Hazel Poyntz, Nick Shortt, Angela Jones, Aurélie Gestin, Katie Gell, Alix Grooby, David O’Sullivan, Jeffry S Tang, Wayne Young, Darmiga Thayabaran, Jenny Sparks, Tess Ostapowicz, Audrey Tay, Sally D Poppitt, Sarah Elliott, Georgia Wakefield, Amber Parry-Strong, Jacqui Ralston, Richard Beasley, Mark Weatherall, Irene Braithwaite, Elizabeth Forbes-Blom, Olivier Gasser
DOI: 10.3389/fimmu.2021.765528
2021
Practical Approach To Explore the Effects of Polyphenols on Aryl Hydrocarbon Receptor Regulated Immune Function
Jeffry S Tang, Alissa Cait, Yanyan Li, Helena Abolins-Thompson, Katie Gell, Patries M Herst, David O’Sullivan, Olivier Gasser
DOI: 10.1021/acs.jafc.1c02095
2021
MR1-dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis
Karmella Naidoo, Katherine Woods, Christophe Pellefigues, Alissa Cait, David O’Sullivan, Katie Gell, Andrew J Marshall, Regan J Anderson, Yanyan Li, Alfonso Schmidt, Kef Prasit, Johannes U Mayer, Aurelie Gestin, Ian F Hermans, Gavin Painter, Elizabeth A Jacobsen, Olivier Gasser
DOI: 10.1111/all.14994
2021
pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis
Liang Xie, Craig I McKenzie, Xinyan Qu, Yan Mu, Quanbo Wang, Nan Bing, Karmella Naidoo, Md Jahangir Alam, Di Yu, Fang Gong, Caroline Ang, Remy Robert, Francine Z Marques, Nicholas Furlotte, David Hinds, Olivier Gasser, 23andMe Research Team, Ramnik J Xavier, Charles R Mackay
DOI: 10.4049/jimmunol.2001363
2021
Basophils promote barrier dysfunction and resolution in the atopic skin
Christophe Pellefigues, Karmella Naidoo, Palak Mehta, Alfonso J Schmidt, Ferdinand Jagot, Elsa Roussel, Alissa Cait, Bibek Yumnam, Sally Chappell, Kimberley Meijlink, Mali Camberis, Jean X Jiang, Gavin Painter, Kara Filbey, Özge Uluçkan, Olivier Gasser, Graham Le Gros
DOI: 10.1016/j.jaci.2021.02.018
2021
Mānuka honey-derived methylglyoxal enhances microbial sensing by mucosal-associated invariant T cells
Jeffry S Tang, Benjamin J Compton, Andrew Marshall, Regan Anderson, Yanyan Li, Hannah van der Woude, Ian F Hermans, Gavin F Painter, Olivier Gasser
DOI: 10.1039/d0fo01153c
2020
Innate-like T cells in the context of metabolic disease and novel therapeutic targets
Hannah van der Woude, Jeremy Krebs, Sara Filoche, Olivier Gasser
DOI: 10.20900/immunometab20200031
2020
Distinct Dysfunctional States of Circulating Innate-Like T Cells in Metabolic Disease
Yanyan Li, Katherine Woods, Amber Parry-Strong, Regan J Anderson, Celina Capistrano, Aurelie Gestin, Gavin F Painter, Ian F Hermans, Jeremy Krebs, Olivier Gasser
DOI: 10.3389/fimmu.2020.00448
2020
Enhancing T cell responses and tumour immunity by vaccination with peptides conjugated to a weak NKT cell agonist
Benjamin J Compton, Kathryn J Farrand, Ching-Wen Tang, Taryn L Osmond, Mary Speir, Astrid Authier-Hall, Jing Wang, Peter M Ferguson, Susanna T S Chan, Regan J Anderson, Taylor R Cooney, Colin M Hayman, Geoffrey M Williams, Margaret A Brimble, Collin R Brooks, Lin-Kin Yong, Leonid S Metelitsa, Dirk M Zajonc, Dale I Godfrey, Olivier Gasser, Robert Weinkove, Gavin F Painter, Ian F Hermans
DOI: 10.1039/c8ob02982b
2019
A reverse metabolic approach to weaning: in silico identification of immune-beneficial infant gut bacteria, mining their metabolism for prebiotic feeds and sourcing these feeds in the natural product space
Samanta Michelini, Biju Balakrishnan, Silvia Parolo, Alice Matone, Jane A Mullaney, Wayne Young, Olivier Gasser, Clare Wall, Corrado Priami, Rosario Lombardo, Martin Kussmann
DOI: 10.1186/s40168-018-0545-x
2018
A feasibility study: association between gut microbiota enterotype and antibody response to seasonal trivalent influenza vaccine in adults
Nick Shortt, Hazel Poyntz, Wayne Young, Angela Jones, Aurélie Gestin, Anna Mooney, Darmiga Thayabaran, Jenny Sparks, Tess Ostapowicz, Audrey Tay, Sally Poppitt, Sarah Elliott, Georgia Wakefield, Amber Parry-Strong, Jacqui Ralston, Olivier Gasser, Richard Beasley, Mark Weatherall, Irene Braithwaite, Elizabeth Forbes-Blom
DOI: 10.1002/cti2.1013
2018
A phase I vaccination study with dendritic cells loaded with NY-ESO-1 and α-galactosylceramide: induction of polyfunctional T cells in high-risk melanoma patients
Olivier Gasser, Katrina J Sharples, Catherine Barrow, Geoffrey M Williams, Evelyn Bauer, Catherine E Wood, Brigitta Mester, Marina Dzhelali, Graham Caygill, Jeremy Jones, Colin M Hayman, Victoria A Hinder, Jerome Macapagal, Monica McCusker, Robert Weinkove, Gavin F Painter, Margaret A Brimble, Michael P Findlay, P Rod Dunbar, Ian F Hermans
DOI: 10.1007/s00262-017-2085-9
2018
Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells
Mariolina Salio, Olivier Gasser, Claudia Gonzalez-Lopez, Anne Martens, Natacha Veerapen, Uzi Gileadi, Jacob G Verter, Giorgio Napolitani, Regan Anderson, Gavin Painter, Gurdyal S Besra, Ian F Hermans, Vincenzo Cerundolo
DOI: 10.4049/jimmunol.1700615
2017
Expression of CD1a and Type-1 Polarization Are Dissociated in Human Monocyte-Derived Dendritic Cells
Brigitta Mester, Evelyn Bauer, Catherine E Wood, Ian F Hermans, Olivier Gasser
DOI: 10.1371/journal.pone.0140432
2015
NKT cell-dependent glycolipid-peptide vaccines with potent anti-tumour activity
Regan J Anderson, Benjamin J Compton, Ching-Wen Tang, Astrid Authier-Hall, Colin M Hayman, Gene W Swinerd, Renata Kowalczyk, Paul Harris, Margaret A Brimble, David S Larsen, Olivier Gasser, Robert Weinkove, Ian F Hermans, Gavin F Painter
DOI: 10.1039/c4sc03599b
2015
A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy
Regan J Anderson, Ching-wen Tang, Naomi J Daniels, Benjamin J Compton, Colin M Hayman, Karen A Johnston, Deborah A Knight, Olivier Gasser, Hazel C Poyntz, Peter M Ferguson, David S Larsen, Franca Ronchese, Gavin F Painter, Ian F Hermans
DOI: 10.1038/nchembio.1640
2014
Epstein-Barr virus negativity among individuals older than 60 years is associated with HLA-C and HLA-Bw4 variants and tonsillectomy
Bojana Durovic, Olivier Gasser, Patrick Gubser, Jörg Sigle, Hans H Hirsch, Martin Stern, Andreas Buser, Christoph Hess
DOI: 10.1128/JVI.00169-13
2013
Expansion of interferon-γ-secreting HIV-specific T cells during successful antiretroviral therapy
O Gasser, C Brander, M Wolbers, N V Brown, A Rauch, H F Günthard, M Battegay, C Hess; Swiss HIV Cohort Study
DOI: 10.1111/j.1468-1293.2012.01040.x
2013
Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection
Matthew R Henn, Christian L Boutwell, Patrick Charlebois, Niall J Lennon, Karen A Power, Alexander R Macalalad, Aaron M Berlin, Christine M Malboeuf, Elizabeth M Ryan, Sante Gnerre, Michael C Zody, Rachel L Erlich, Lisa M Green, Andrew Berical, Yaoyu Wang, Monica Casali, Hendrik Streeck, Allyson K Bloom, Tim Dudek, Damien Tully, Ruchi Newman, Karen L Axten, Adrianne D Gladden, Laura Battis, Michael Kemper, Qiandong Zeng, Terrance P Shea, Sharvari Gujja, Carmen Zedlack, Olivier Gasser, Christian Brander, Christoph Hess, Huldrych F Günthard, Zabrina L Brumme, Chanson J Brumme, Suzane Bazner, Jenna Rychert, Jake P Tinsley, Ken H Mayer, Eric Rosenberg, Florencia Pereyra, Joshua Z Levin, Sarah K Young, Heiko Jessen, Marcus Altfeld, Bruce W Birren, Bruce D Walker, Todd M Allen
DOI: 10.1371/journal.ppat.1002529
2012
Treatment-dependent loss of polyfunctional CD8+ T-cell responses in HIV-infected kidney transplant recipients is associated with herpesvirus reactivation
O Gasser, F Bihl, S Sanghavi, C Rinaldo, D Rowe, C Hess, D Stablein, M Roland, P Stock, C Brander
